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While this observational study cannot prove causation, it raises important questions about whether GLP-1s could become part of future strategies for substance use disorders, overdose prevention, and post-overdose care management

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Treatment ratios for ALT change vs placebo at weeks 30, 56 and 104 in the cardiovascular outcomes trial are shown in Figure S3A (unadjusted for weight change) and S3B (adjusted for weight change)

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